Here's how they're different.

LabelMANAGER 350 is a powerful desktop thermal transfer printer that saves up to ten labels in memory, prints up to four lines of tall characters in eight styles: normal, narrow, bold, vertical, italic, outline, shadow and mirror. Features include a 2-line, 15-character LCD for easy editing and an array of background effects. Comfortable typewriter-style keyboard includes electrical symbols and bar codes. The large LCD display, economical thermal printing and a built-in "bonus" tax calculator make this a DYMO favorite.

Label compatibility: Prints five label. widths: 1/4" (6 mm), 3/8" (9 mm), 1/2" (12 mm), 3/4" (19 mm) and 1" (24 mm).

LabelMANAGER 450 works independently - or with your PC and DYMO software - as a powerful electronic labeler for signs and other heavy-duty applications. This exciting labeling advance combines cutting-edge design, unparalleled functionality, and economical thermal printing with features including an automatic cutter for added speed, typewriter-style keyboard with profiled keys for error-free use and an eye-saving LCD display with large characters. Produces barcodes, logos, graphics and all your favorite fonts on up to five lines per label in: 15 sizes and 11 styles, with seven background patterns.

Label compatibility: Prints five label widths: 1/4" (6 mm), 3/8" (9 mm), 1/2" (12 mm), 3/4" (19 mm) and 1" (24 mm).

LabelMANAGER PC is the electronic printer that connects to your PC and its USB port to let your imagination take hold in the form of permanent, high-quality labels up to 1" wide. Includes label design software for creating colorful, eye-catching labels from your favorite software programs - complete with text, bolds, italics, outlines, shadow, symbols and graphics. Aligns left, centered, right and more.

Label compatibility: Prints five label widths: 1/4" (6 mm), 3/8" (9 mm), 1/2" (12 mm), 3/4" (18 mm) and 1" (24 mm).